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刘建玲
发布时间:2021-03-24      作者:    点击:[]    分享到:

个人简介


刘建玲,博士、三级教授、博士生导师。
本科:1985年毕业于延安大学医学系;
博士:2006年毕业于西北农林科技大学动物科技学院;
博士后:2009年于西北农林科技大学全球十大正规外围买球平台博士后流动站出站。
国外访学:1992.9-1994.6期间,在日本上智大学药学院做访问学者。
于2000年9月在全球十大正规外围买球平台任教。任教期间承担体育外围平台网址生命科学院本科生、研究生的《微生物学》、《医学微生物学》、《医学营养学》、《微生物学进展》及《分子免疫学》等专业基础课、学位课的教学工作。兼有医学、动物医学及系统药理学等专业研究背景,主要在病原微生物、药用植物学及系统药理学领域从事研究及产品开发工作。

主要研究方向:
病原微生物及基因工程疫苗;药用植物内生菌的代谢及调控;药用植物学的系统药理学;中草药复方活性成分预测和筛选。近期主要从事中草药抗癌机制研究及新药研发、中草药天然产物抗抑郁等复杂疾病机制的研究。

承担的科研项目


近年来主持及完成的主要科研课题:
1. 国家自然科学基金项目:
植物内生菌地衣芽孢杆菌对猪肠道致病菌的抑制机理(31540008),主持
2. 陕西省科技厅自然科学基金重点项目:
MGMT调控胶质瘤替莫唑胺治疗抵抗及机制研究(2018JZ3007),主持
3. 陕西省科技厅自然科学基金:
半夏内生菌对猪肠道细菌的抑制作用机理(2014JM3063),主持
4. 陕西省教育厅产业化项目:
绿色无公害微生物发酵饲料添加剂产业化(2010JC22),主持
5. 陕西省科技厅攻关项目:
陕南特色生物资源利用与新产品开发(2009K01-25),主持
6. 中国博士后科学基金面上基金:
药用植物半夏的次生代谢调控研究(20090451400),主持
7. 陕西省教育厅自然基金项目:
猪血管内皮细胞的永生化及表达猪瘟病毒E2基因的研制(编号05JK296),2004.4-2008.4
8.陕西省科技厅自然科学基金:
可溶性炭疽杆菌毒素受体的研制(2002G125),主持
9.陕西省教育厅自然基金项目:
炭疽杆菌毒素的研制(02JK075),主持
10. 陕西省教育厅面向21世纪教学改革项目:
21世纪微生物学实验教学新内容与新体系研究 (0202011),主持
11. 体育外围平台网址科研启动基金:
猪瘟病毒E2基因的研究(okyqdf182),主持

主要研究成果


1. J. Liu, M. Jiang, Z.Li, X. Zhang, X. Li, Y. Hao, X. Su, J. Zhu, C. Zheng, W. Xiao and Y. Wang*. A Novel Systems Pharmacology Method to Investigate Molecular Mechanisms of Scutellaria barbata D. Don for Non-small Cell Lung Cancer[J]. Frontiers in pharmacology, 2018, 9. IF:3.831.
2. J. Liu, J. Liu, F. Shen, Z. Qin, M. Jiang, J. Zhu, Z. Wang, J. Zhou, Y. Fu, X. Chen, C. Huang, W. Xiao *, C. Zheng *, Y. Wang *. Systems pharmacology analysis of synergy of TCM: an example using saffron formula[J]. Scientific reports, 2018, 8(1): 380. IF:4.122
3. J. Liu, J. Zhu, J. Xue, Z. Qin, F. Shen, J. Liu, X. Chen, X. Li, Z. Wu, W. Xiao, C.Zheng*&Y.Wang*. In silico-based screen synergistic drug combinations from herb medicines: a case using Cistanche tubulosa[J]. Scientific reports, 2017, 7(1): 16364. IF: 4.122.
4. J. Liu, J. Mu, C. Zheng, X. Chen, Z. Guo, C. Huang, Y. Fu, G. Tian, H. Shang, Y. Wang*.Systems-Pharmacology Dissection of Traditional Chinese Medicine Reveal s Multi-scale Treatment Strategy for Cardiovascular diseases[J]. Scientific Reports. 2016; 6: 19809. doi: 10.1038/srep19809. IF: 5.228.
5. T. Pei, C. Zheng, C. Huang, X. Chen, Z. Guo, Y. Fu, J. Liu *, Y. Wang *. Systematic understanding the mechanisms of vitiligo pathogenesis and its treatment by Qubaibabuqi formula. Journal of ethnopharmacology, 2016, 190: 272-287. IF: 2.981
6. J. Liu, T. Pei, J. Mu, C. Zheng, X. Chen, C. Huang, Y. Fu, Z. Liang, Y. Wang*. Systems Pharmacology Uncovers the Multiple Mechanisms of Xijiao Dihuang Decoction for the Treatment of Viral Hemorrhagic Fever[J]. Evidence-Based Complementary and Alternative Medicine. 2016 (2016) doi: 10.1155/2016/9025036. IF: 1.88.
7. J. Liu, K. Sun, C. Zheng, X. Chen, W. Zhang, Z. Wang, S. Ali, W. Xiao *, Y. Wang *. Pathway as a Pharmacological Target for Herbal Medicines: An Investigation from Reduning Injection[J]. PLOS ONE. 2015 Apr 1;10(4). IF: 3.234.
8. C. Zheng, J. Wang, J. Liu, M. Pei , C. Huang, Y. Wang *. Systems-level Multi-target Drug Discovery from Natural Products with Applications to Cardiovascular Diseases[J]. J Ethnopharmacol. 2014, 18(3):621-635.IF: 2.998.
9. J. Liu, M. Pei, Y. Wang*. A Systems-Pharmacology Analysis of Herbal Medicines.Used in Health Improvement Treatment: Predicting Potential New Drugs and Targets[J]. Evidence-Based Complementary and Alternative Medicine. 2013, (938764):1-17. IF: 1.88.
10. J. Liu, M. Liu, Y. Yao, J. Wang, Y. Li, G. Li, Y. Wang*. Identification of novel potential β-N-Acetyl-D-hexosaminidase inhibitors by virtual screening, molecular dynamics simulation and MM-PBSA calculations[J]. Int. J. Mol. Sci. 13(4):4545-4563, 2012. IF: 2.862.
11. F. Wang, M. Liu, J. Liu*. In silico prediction of inhibitory effects of pyrazol-5-one and indazole derivatives on GSK3 beta kinase enzyme[J]. J. Mol. Struct. 1024:94-103, 2012. IF: 1.602.
12. J. Liu, Y. Lei, F. Wang, Y. Yi, Y. Liu, Y. Wang*. Immunostimulatory activities of specific bacterial secondary metabolite of anoxybacillus flavithermus strain SX-4 on carp[J. Cyprinus carpio. J. Appl. Microbiol. 110(4):1056-1064, 2011. IF: 2.479.
13. J. Liu, F. Wang, Z. Ma, X. Wang, Y. Wang*. Structural determination of three different series of compounds as Hsp90 inhibitors using 3D-QSAR modeling, molecular docking and molecular dynamics methods[J]. Int. J. Mol. Sci. 12(2):946-970, 2011. IF: 2.862.
14. J. Liu, H. Zhang, Z. Xiao, F. Wanf, X. Wang, Y. Wang*. Combined 3D-QSAR, molecular docking and molecular dynamics study on derivatives of peptide epoxyketone and tyropeptin-boronic acid as inhibitors against β5 subunit of human 20S proteasome[J]. Int. J. Mol. Sci. 12(3):1807-1835, 2011. IF: 2.862.
15. Y. Liu, Z. Liang*. Chen, D. Yang, J. Liu. Elicitation of alkaloids in vitro PLB (protocorm-like body) cultures of Pinellia ternate[J]. Enz. Microb .Tech. 2010 (46): 28–31. IF: 2.322.
16. Y. Liu, Z. Liang*, J. Liu. Use of protocorm-like bodies for studying alkaloid metabolism in Pinellia ternate[J]. Plant Cell Tiss. Org. Cult. 2009, 46(1): 28-31. IF: 2.125.
17. Y. Liu, Z. Liang*, J. Liu. L C Fingerprinting for Assessment of the Quality of the Lipophilic Components of Salvia miltiorrhiza[J]. Chromatographia. 2009, 69 (5-6): 555-560. IF: 1.411.
SCIE:
1. J. Liu, C. Zheng, Y. Wang*.Perspective: Systems Pharmacology Strategy for Investigation of Antioxidant Drugs and Its Mechanisms of Action[J]. Journal of Bioequivalence & Bioavailability. 2014: 6(2):1-3.

获得的教学和科研表彰


1. 2016年9月获体育外围平台网址优秀教师称号。
2. 2015年获教学成果二等奖。